Chemist Confessions

#172) THEY CLAIM THIS WILL WORK! Reviewing Retinal products!

In this episode, we are diving deep into the retinal (retinaldehyde) landscape to see how current market offerings stack up. Following our technical breakdown of retinol versus retinal, we shift our focus to real-world testing of popular formulations from Krave Beauty, Prequel, Celimax, and Medik8. We examine the scientific validity of concentration ranges—from the entry-level 0.05% to the more intense 0.24%—and discuss how different textures and price points impact the user experience for various skin types. Whether you are a retinoid rookie or a seasoned pro, we provide the detailed assessment on the data to find the right one for your particular skinario.

 

Timestamps:

00:00 - Intro

02:18 - Product Aesthetics & Textures

08:35 - Krave Beauty 24 Retinal Decode

10:21 - Prequel Retinal Renewal Decode

15:48 - Celimax Vita-A Retinal Shot Decode

22:00 - Medik8 Crystal Retinal 6 Decode

23:51 - Is Retinal 11x faster than Retinol?

28:39 - Chemists' Favorite Retinal (Personal favorites and usage recommendations)

 

Products Mentioned: Shop everything mentioned in this video here: https://shopmy.us/collections/4698294 PREQUEL | Retinal Renew Retinaldehyde Gel: https://go.shopmy.us/p-51236222 CELIMAX | The Vita-A Retinal Shot Tightening Booster: https://go.shopmy.us/p-51236269 KRAVEBEAUTY | 24 Carrot Retinal Gentle 0 05 Retinal Serum: https://go.shopmy.us/p-51236391 MEDIK8 | Crystal Retinal 6 Serum: https://go.shopmy.us/p-51236422 (use code: CHEMISTCONFESSIONS for 15% off) Shop more of my favorite products here: https://shopmy.us/chemistconfessions

 

 

#171) We have to talk about this again: RETINOL VS RETINAL

We are diving back into the "rumor mill" of the retinoid world! Is Retinal actually better than Retinol, or is it just better marketing?
In this episode, we revisit the Retinol vs. Retinal debate with new 2026 data. We break down what the evidence says about the retinoid conversion pathway into retinoic acid. We look at the latest clinical evidence to help you decide if it’s time to switch your anti-aging active or stay the course with your current skincare routine.

Episode Timestamps
0:00 - Intro: Revisiting the Retinoid Rumor Mill
1:34 - Why Retinal (Retinaldehyde) is Growing in Popularity
2:01 - The Science of Retinoic Acid Conversion Steps
5:30 - What the Data Shows (Retinol vs. Retinal ex vivo Conversion)
9:15 - Retinal vs. Retinol: Potency & Efficacy Realities
14:40 - Is Retinal Actually Gentler? (Irritation & Skin Barrier)
18:20 - Debunking High-Concentration Retinoid Myths
23:55 - Reviewing Recent Retinal Product Launches
28:10 - How to Choose: Retinol or Retinal for your Skin Type?
36:22 - Final Verdict: Should You Switch Your Active?

Resources & Mentions

Retinal vs Retinol on the CC Blog: https://chemistconfessions.com/blogs/retinal-is-it-better-than-retinol
Retinol vs Tretinoin: https://chemistconfessions.com/blogs/tretinoin-vs-retinol
Follow us on IG : @chemist.confessions

#chemistconfessions #retinal #retinol #skincarescience #antiaging #retinaldehyde #skincareroutine

#170) WE ARE ENDING THIS! Hyperpigmentation Finale!

We are taking a break from hyperpigmentation actives! In this finale, we tie together months of research to help you build the ultimate hyperpigmentation skincare routine.
We rank the actives from our last 10 episodes—including Hydroquinone, Azelaic acid, Arbutin, Glutathione, Thiamodol, Symwhite, etc. —from S-Tier (Gold Standard) to Tier “Meh.” We also filter through the 18 products we tested down to the ones we think should be on your radar and warn you about "Niacinamide Overload."

Timestamps:
0:00 - Intro: Our Hyperpigmentation Journey Recap
1:34 - How to Build a Hyperpigmentation Routine Framework
3:37 - S-Tier Actives: The Most Effective Brightening Ingredients
5:44 - A-Tier: Reliable, Well-Tested Actives for Dark Spots
7:12 - B-Tier: Decent but with some caveats
10:23 - C-Tier & "Meh"
14:17 - Top Product Recommendations: which ones should you actually try?
21:07 - The Niacinamide Math: Avoid Potential Skin Irritation from Overlayering

Product Links
LA ROCHE-POSAY | Mela B3 Dark Spot Serum with Melasyl + Niacinamide: https://go.shopmy.us/p-47880551 (use code: CHEMISTCONFESSIONS10 for 10% off)
EUCERIN | Radiant Tone Dual Serum Dark Spot Corrector: https://go.shopmy.us/p-47881019
ULTA | The Alpha-Arbutin 2 Discoloration Care Serum: https://go.shopmy.us/p-49134844
ANUA | Azelaic Acid 10 Hyaluron Redness Soothing Serum: https://go.shopmy.us/p-49134854
PAULA'S CHOICE | 25% Vitamin C + Glutathione Clinical Serum: https://go.shopmy.us/p-49134896
Numbuzin Glutahione TXA Advanced Dark Spot Ampoule Concentrate: https://go.shopmy.us/p-49134975

Shop more of my favorite products here: https://shopmy.us/chemistconfessions

#169) Reviewing Resorcinol stuff!

CHECK OUT DOUBLE PLAY!: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

We follow up our deep dive into resorcinols by featuring five specific products that highlight these key ingredients for hyperpigmentation!

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

#168) Resorcinol Part 2!

CHECK OUT DOUBLE PLAY!: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

We are wrapping up our hyperpigmentation series by diving into the science of resorcinol and its various derivatives. We explore the history of this "ancient" molecule, its uses in treatments like designer peels and acne prescriptions, and why the industry has shifted toward modern derivatives to avoid skin irritation.

00:21 | Part 2: Continuing our Resorcinol Series 
00:35 | What is Hexylresorcinol? 
00:49 | Hexylresorcinol vs. 2% Hydroquinone: The Study Breakdown 
01:07 | Testing Parameters: 1% Hexylresorcinol Concentration 
01:37 | Analyzing the Results: Expert Grading and Data 
01:53 | 12-Week Results: Significant Improvements in Pigmentation 
02:03 | Comparing Performance to Hydroquinone 
25:22 | Major Formulation Challenges with Resorcinols
25:33 | Conclusion and What’s Coming Next

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

#167) Resorcinol! (But really its cousins)

CHECK OUT DOUBLE PLAY!: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

We are wrapping up our hyperpigmentation series by diving into the science of resorcinol and its various derivatives. We explore the history of this "ancient" molecule, its uses in treatments like designer peels and acne prescriptions, and why the industry has shifted toward modern derivatives to avoid skin irritation.

01:28 | What is resorcinol? 
01:50 | Resorcinol in acne treatments and designer peels 
02:13 | Why is resorcinol used in hair dyes? 
02:33 | The shift toward resorcinol derivatives for skin safety 
02:54 | EU SCC regulations on resorcinol concentrations 
22:30 | Hyperpigmentation serum scenarios and skin discomfort
23:05 | Preview: Hexylresorcinol and Diamond Oil

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

#166) Reviewing 5 Glutathione Products!

We are back for a follow-up to our glutathione deep dive! We review five specific glutathione-heavy products, four from the K-beauty world and one popular Amazon find, to see if they truly deliver on their antioxidant and brightening claims.

00:00 | Intro: Hashtags & antioxidant claims
00:24 | Welcome back to Chemist Confessions Podcast
00:30 | Glutathione deep dive follow-up
00:56 | Product lineup: 4 K-beauty + 1 Paula’s Choice
02:05 | Price points & supply differences
03:40 | Texture notes: neutral, not hydrating
05:03 | Fragrance issues & masking glutathione scent
06:05 | Stability concerns & 2-week shelf life
07:23 | Paula’s Choice texture & film discussion
08:25 | The infamous “eggy with undertone of death” scent
10:16 | Clinical claims & before/after photos skepticism
12:04 | Niacinamide + tranexamic acid doing the heavy lifting
17:57 | Tulsa Wound serum: 2% glutathione, suspicious photos
21:03 | Abib serum: percentages, encapsulation, and clinical data

Product Shoutout: Double Play Retinol Face and Eye Treatment:
https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

 

 

#165: We are finally talking about this ingredient: GLUTATHIONE!

WE HEARD YOU! We explore the science behind one of the most requested and hyped ingredients skincare sector: glutathione. We break down what this "master antioxidant" actually is.

01:25 | What is Glutathione? Breaking down the tri-peptide 
01:54 | Why is it called the "Master Antioxidant"? 
02:43 | Mechanisms: Tyrosinase inhibition and skin whitening 
03:16 | The Stability Struggle: Why pH and temperature matter 
06:18 | Half-life study: How quickly does it degrade in your products? 
08:12 | Gold Standard Age Booster: Tactical hyperpigmentation tool 
08:40 | Does it actually work? Reviewing topical clinical studies 
12:35 | Study Deep Dive: 0.5% GSH vs. placebo on Indonesian women 
17:36 | Oxidized Glutathione (GSSG): Is a more stable version better?

Product Shoutout: Double Play Retinol Face and Eye Treatment:
https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

#164) The Drugstore Level Alpha Arbutin Landscape

We explore the science of skincare as we review five affordable, drugstore-priced arbutin products. In this episode, we break down everything from texture and clinical claims and ingredient lists of popular brands to help you find the right formula for your skin.

TIMESTAMPS: 
01:27 | Texture Analysis: Why is Arbutin so Sticky?
03:01 | Texture Face-Off: Oily vs. Dry Skin Reactions
04:48 | Is the Beauty of Joseon Serum a Moisturizer?
06:01 | Chemist Notes: Breaking Down the Cosrx Formula
06:57 | Analyzing Clinical Claims: Inner and Outer Melanin?
09:57 | Instrumental Measurements: Reducing Dark Spots
13:01 | Deep Dive: Beauty of Joseon Ingredients
14:56 | The Truth About "Pregnancy Safe" Marketing
16:25 | The Ordinary & Naturium: Simple Serum Breakdown

Product Shoutout: Double Play Retinol Face and Eye Treatment:
https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

#163 ) The Science of Arbutin: Does It Actually Clear Dark Spots?

We are diving deep into the science of skincare to explore the role of Arbutin in treating hyperpigmentation. In this human conversation, we break down what exactly Arbutin is, analyze the existing data on its efficacy, and provide a comprehensive guide on what you should consider when shopping for these products.

 

 

Product Shoutout: Double Play Retinol Face and Eye Treatment:
https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment

Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc

Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams 

Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes...

Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack